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Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2015
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3 tweeters

Citations

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9 Dimensions

Readers on

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37 Mendeley
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Title
Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
Published in
Memórias do Instituto Oswaldo Cruz, February 2015
DOI 10.1590/0074-02760140330
Pubmed ID
Authors

Thiago Moreno Lopes e Souza, Natalia Fintelman-Rodrigues, Paola Cristina Resende, Milene Mesquita, Tatiana Schaffer Gregianini, Fernando A Bozza, Ana Carla Pecego, Sandra Bianchini Fernandes, Ana Luisa Furtado Cury, Irina Nastassja Riediger, Marilda M Siqueira

Abstract

The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations. We display the permissive mutations in NA of OST-resistant A(H1N1)pdm09 virus found in Brazilian community settings. The NAs from 2013 are phylogenetically distinct from those of 2012, indicating a tendency of positive selection of NAs with better fitness. Some previously predicted permissive mutations, such as V241I and N369K, found in different countries, were also detected in Brazil. Importantly, the change D344N, also predicted to compensate loss of fitness imposed by H275Y mutation, was found in Brazil, but not in other countries in 2013. Our results reinforce the notion that OST-resistant A(H1N1)pdm09 strains with compensatory mutations may arise in an independent fashion, with samples being identified in different states of Brazil and in different countries. Systematic circulation of these viral strains may jeopardise the use of the first line of anti-influenza drugs in the future.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
Unknown 35 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 22%
Researcher 7 19%
Student > Master 6 16%
Student > Doctoral Student 2 5%
Student > Postgraduate 2 5%
Other 6 16%
Unknown 6 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 22%
Agricultural and Biological Sciences 5 14%
Immunology and Microbiology 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Veterinary Science and Veterinary Medicine 2 5%
Other 9 24%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2016.
All research outputs
#13,198,406
of 19,884,221 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#819
of 1,250 outputs
Outputs of similar age
#131,588
of 228,229 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#11
of 27 outputs
Altmetric has tracked 19,884,221 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,250 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,229 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.