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Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2015
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Title
Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products
Published in
Memórias do Instituto Oswaldo Cruz, February 2015
DOI 10.1590/0074-02760140332
Pubmed ID
Authors

Emeline Houël, German Gonzalez, Jean-Marie Bessière, Guillaume Odonne, Véronique Eparvier, Eric Deharo, Didier Stien

Abstract

This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydrodistilled. Using broth microdilution techniques, the obtained EOs were tested against three strains of dermatophytes (Trichophyton mentagrophytes, Microsporum gypseum and Microsporum canis). To compare the EOs antifungal and antiparasitic effects, the EOs activities against axenic amastigotes of L. amazonensis were concurrently evaluated. For the most promising EOs, their antileishmanial activities against parasites infecting peritoneal macrophages of BALB/c mice were measured. The most interesting antifungal candidates were the EOs from Cymbopogon citratus, Otacanthus azureus and Protium heptaphyllum, whereas O. azureus, Piper hispidum and P. heptaphyllum EOs exhibited the lowest 50% inhibitory concentration (IC50) values against axenic amastigotes, thus revealing a certain correspondence between both activities. The P. hispidum EO was identified as the most promising product in the results from the infected macrophages model (IC50: 4.7 µg/mL, safety index: 8). The most abundant compounds found in this EO were sesquiterpenes, notably curzerene and furanodiene. Eventually, the evaluation of the antidermatophytic activity of EOs appears to be an efficient method for identifying new potential drugs for the treatment of L. amazonensis.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 4%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 20%
Researcher 10 18%
Student > Bachelor 5 9%
Professor 4 7%
Other 3 5%
Other 10 18%
Unknown 13 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 20%
Pharmacology, Toxicology and Pharmaceutical Science 10 18%
Chemistry 5 9%
Medicine and Dentistry 5 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 5 9%
Unknown 18 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2015.
All research outputs
#11,127,491
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#761
of 862 outputs
Outputs of similar age
#180,145
of 216,938 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#9
of 12 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 216,938 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.