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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures
|
|---|---|
| Published in |
Nature Neuroscience, April 2018
|
| DOI | 10.1038/s41593-018-0130-4 |
| Pubmed ID | |
| Authors |
Cian McCafferty, François David, Marcello Venzi, Magor L. Lőrincz, Francis Delicata, Zoe Atherton, Gregorio Recchia, Gergely Orban, Régis C. Lambert, Giuseppe Di Giovanni, Nathalie Leresche, Vincenzo Crunelli |
| Abstract |
Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channel (T-channel)-dependent burst firing in thalamocortical (TC) neurons and by temporally framing thalamic output via feedforward reticular thalamic (NRT)-to-TC neuron inhibition. In TC neurons, overall ictal firing was markedly reduced and bursts rarely occurred. Moreover, blockade of T-channels in cortical and NRT neurons suppressed ASs, but such blockade in TC neurons had no effect on seizures or on ictal thalamic output synchrony. These results demonstrate ictal bidirectional cortico-thalamic communications and provide the first mechanistic understanding of cortico-thalamo-cortical network firing dynamics during ASs in behaving animals. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 9% |
| United States | 3 | 9% |
| Spain | 2 | 6% |
| Malta | 1 | 3% |
| Mexico | 1 | 3% |
| Switzerland | 1 | 3% |
| Egypt | 1 | 3% |
| Unknown | 20 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 81% |
| Scientists | 3 | 9% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 25% |
| Student > Ph. D. Student | 34 | 22% |
| Student > Master | 15 | 9% |
| Student > Bachelor | 10 | 6% |
| Student > Postgraduate | 7 | 4% |
| Other | 21 | 13% |
| Unknown | 32 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 70 | 44% |
| Agricultural and Biological Sciences | 21 | 13% |
| Medicine and Dentistry | 12 | 8% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Engineering | 3 | 2% |
| Other | 9 | 6% |
| Unknown | 40 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2018.
All research outputs
#831,730
of 24,250,928 outputs
Outputs from Nature Neuroscience
#1,430
of 5,421 outputs
Outputs of similar age
#17,880
of 300,145 outputs
Outputs of similar age from Nature Neuroscience
#34
of 67 outputs
Altmetric has tracked 24,250,928 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.