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Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment

Overview of attention for article published in Jornal Brasileiro de Pneumologia
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Title
Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment
Published in
Jornal Brasileiro de Pneumologia
DOI 10.1590/s1806-37132015000100009
Pubmed ID
Authors

Suzie Hyeona Kang, Paulo de Tarso Roth Dalcin, Otavio Bejzman Piltcher, Raphaella de Oliveira Migliavacca

Abstract

Although cystic fibrosis (CF) is an irreversible genetic disease, advances in treatment have increased the life expectancy of CF patients. Upper airway involvement, which is mainly due to pathological changes in the paranasal sinuses, is prevalent in CF patients, although many are only mildly symptomatic (with few symptoms). The objective of this literature review was to discuss the pathophysiology and current therapeutic management of chronic rhinosinusitis (CRS) in CF patients. The review was based on current evidence, which was classified in accordance with the Oxford Centre for Evidence-Based Medicine criteria. When symptomatic, CRS with nasal polyps can affect quality of life and can lead to pulmonary exacerbations, given that the paranasal sinuses can be colonized with pathogenic bacteria, especially Pseudomonas aeruginosa. Infection with P. aeruginosa plays a crucial role in morbidity and mortality after lung transplantation in CF patients. Although clinical treatment of the upper airways is recommended as initial management, this recommendation is often extrapolated from studies of CRS in the general population. When sinonasal disease is refractory to noninvasive therapy, surgery is indicated. Further studies are needed in order to gain a better understanding of upper airway involvement and improve the management of CRS in CF patients, with the objective of preserving lung function and avoiding unnecessary invasive procedures.

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Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Professor 1 2%
Student > Ph. D. Student 1 2%
Student > Doctoral Student 1 2%
Student > Master 1 2%
Unknown 38 90%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Nursing and Health Professions 1 2%
Medicine and Dentistry 1 2%
Unknown 39 93%