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Even high-dose extended infusions may not yield desired concentrations of β-lactams: the value of therapeutic drug monitoring

Overview of attention for article published in Infectious Diseases, March 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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4 X users

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37 Mendeley
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Title
Even high-dose extended infusions may not yield desired concentrations of β-lactams: the value of therapeutic drug monitoring
Published in
Infectious Diseases, March 2015
DOI 10.3109/23744235.2015.1021831
Pubmed ID
Authors

Menino Osbert Cotta, Belinda Gowen, Natasha Truloff, Evan Bursle, Brett McWhinney, Jacobus P.J. Ungerer, Jason A. Roberts, Jeffrey Lipman

Abstract

A 35-year-old patient in intensive care with severe burn injury developed episodes of sepsis. Blood culture yielded a multidrug-resistant Pseudomonas aeruginosa and treatment was commenced with amikacin (minimum inhibitory concentration (MIC) 2-4 mg/L, dose 20 mg/kg adjusted body weight 24-hourly) and meropenem (MIC 8 mg/L, dose 2 g IV 8-hourly and later 6-hourly). Despite the use of extended infusions with β-lactam therapeutic drug monitoring and doses that were more than 2.5 times higher than standard meropenem doses, resistance emerged. This case report describes the application of therapeutic drug monitoring to optimize β-lactam therapy in a difficult-to-treat critically ill patient.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 16%
Researcher 6 16%
Student > Master 6 16%
Professor > Associate Professor 4 11%
Lecturer 3 8%
Other 4 11%
Unknown 8 22%
Readers by discipline Count As %
Medicine and Dentistry 15 41%
Pharmacology, Toxicology and Pharmaceutical Science 5 14%
Immunology and Microbiology 3 8%
Biochemistry, Genetics and Molecular Biology 2 5%
Agricultural and Biological Sciences 1 3%
Other 3 8%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2016.
All research outputs
#13,627,467
of 23,509,253 outputs
Outputs from Infectious Diseases
#204
of 601 outputs
Outputs of similar age
#123,246
of 260,227 outputs
Outputs of similar age from Infectious Diseases
#7
of 35 outputs
Altmetric has tracked 23,509,253 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 601 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,227 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.