Title |
Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
|
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Published in |
Journal of Medical Case Reports, April 2018
|
DOI | 10.1186/s13256-018-1629-8 |
Pubmed ID | |
Authors |
Toyonobu Tsuda, Hayato Tada, Yoshihiro Tanaka, Naoto Nishida, Taiji Yoshida, Takeshi Sawada, Kenji Sakata, Kenshi Hayashi, Masa-aki Kawashiri, Takeru Oyama, Motoko Sasaki, Nozomu Kurose, Masakazu Yamagishi |
Abstract |
Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury. We report the clinical and histological features of two contrasting Japanese patients with amiodarone-induced reversible and irreversible hepatotoxicity. One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone. We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. |
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Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 12% |
Student > Ph. D. Student | 4 | 9% |
Professor > Associate Professor | 3 | 7% |
Lecturer | 2 | 5% |
Professor | 2 | 5% |
Other | 9 | 21% |
Unknown | 18 | 42% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Social Sciences | 2 | 5% |
Economics, Econometrics and Finance | 1 | 2% |
Other | 2 | 5% |
Unknown | 18 | 42% |