Title |
Atypical coordination of cortical oscillations in response to speech in autism
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Published in |
Frontiers in Human Neuroscience, March 2015
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DOI | 10.3389/fnhum.2015.00171 |
Pubmed ID | |
Authors |
Delphine Jochaut, Katia Lehongre, Ana Saitovitch, Anne-Dominique Devauchelle, Itsaso Olasagasti, Nadia Chabane, Monica Zilbovicius, Anne-Lise Giraud |
Abstract |
Subjects with autism often show language difficulties, but it is unclear how they relate to neurophysiological anomalies of cortical speech processing. We used combined EEG and fMRI in 13 subjects with autism and 13 control participants and show that in autism, gamma and theta cortical activity do not engage synergistically in response to speech. Theta activity in left auditory cortex fails to track speech modulations, and to down-regulate gamma oscillations in the group with autism. This deficit predicts the severity of both verbal impairment and autism symptoms in the affected sample. Finally, we found that oscillation-based connectivity between auditory and other language cortices is altered in autism. These results suggest that the verbal disorder in autism could be associated with an altered balance of slow and fast auditory oscillations, and that this anomaly could compromise the mapping between sensory input and higher-level cognitive representations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 19% |
Chile | 1 | 6% |
Germany | 1 | 6% |
Mexico | 1 | 6% |
United Kingdom | 1 | 6% |
Canada | 1 | 6% |
Unknown | 8 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 63% |
Scientists | 3 | 19% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 1% |
United States | 2 | 1% |
United Kingdom | 2 | 1% |
Germany | 1 | <1% |
Hungary | 1 | <1% |
Unknown | 142 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 37 | 25% |
Student > Ph. D. Student | 33 | 22% |
Student > Master | 19 | 13% |
Student > Doctoral Student | 7 | 5% |
Student > Bachelor | 6 | 4% |
Other | 20 | 13% |
Unknown | 28 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 36 | 24% |
Neuroscience | 28 | 19% |
Agricultural and Biological Sciences | 13 | 9% |
Linguistics | 8 | 5% |
Medicine and Dentistry | 8 | 5% |
Other | 20 | 13% |
Unknown | 37 | 25% |