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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vagus nerve stimulation: A new bioelectronics approach to treat rheumatoid arthritis?
|
|---|---|
| Published in |
Best Practice & Research Clinical Rheumatology, November 2014
|
| DOI | 10.1016/j.berh.2014.10.015 |
| Pubmed ID | |
| Authors |
F.A. Koopman, P.R. Schuurman, M.J. Vervoordeldonk, P.P. Tak |
| Abstract |
There has been a marked improvement in the treatment of rheumatoid arthritis (RA), but most patients do not achieve disease remission. Therefore, there is still a need for new treatments. By screening an adenoviral short hairpin RNA library, we discovered that knockdown of the nicotinic acetylcholine receptor type 7 (α7nAChR) in RA fibroblast-like synoviocytes results in an increased production of mediators of inflammation and degradation. The α7nAChR is intimately involved in the cholinergic anti-inflammatory pathway (CAP). This led us to study the effects of α7nAChR activation in an animal model of RA, and we could show that this resulted in reduced arthritis activity. Accordingly, stimulation of the CAP by vagus nerve stimulation improved experimental arthritis. Conversely, we found aggravation of arthritis activity after unilateral cervical vagotomy as well as in α7nAChR-knockout mice. Together, these data provided the basis for exploration of vagus nerve stimulation in RA patients as a novel anti-inflammatory approach. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Australia | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 1% |
| United States | 1 | <1% |
| Unknown | 149 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 20% |
| Student > Ph. D. Student | 28 | 18% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 13 | 9% |
| Student > Doctoral Student | 11 | 7% |
| Other | 28 | 18% |
| Unknown | 27 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 26% |
| Agricultural and Biological Sciences | 16 | 11% |
| Engineering | 15 | 10% |
| Neuroscience | 14 | 9% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Other | 25 | 16% |
| Unknown | 33 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2023.
All research outputs
#7,047,316
of 25,374,647 outputs
Outputs from Best Practice & Research Clinical Rheumatology
#316
of 813 outputs
Outputs of similar age
#89,342
of 369,141 outputs
Outputs of similar age from Best Practice & Research Clinical Rheumatology
#4
of 17 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 813 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.