Title |
Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report
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Published in |
BMC Cancer, February 2015
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DOI | 10.1186/s12885-015-1044-0 |
Pubmed ID | |
Authors |
Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini, Chiara Castelli |
Abstract |
Clear cell sarcoma (CCS), initially named malignant melanoma of soft parts, is an aggressive soft tissue sarcoma (STS) that, due to MITF activation, shares with melanoma the expression of melanocyte differentiation antigens. CCS is poorly sensitive to chemotherapy. Multi-kinase inhibitors have been used as therapeutic agents. In the case we report here, treatment with sunitinib induced a long-lasting clinical response that was associated with an immune activation directed against Melan-A/MART-1 antigen. |
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