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EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation

Overview of attention for article published in Journal of Neuroinflammation, March 2015
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Title
EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation
Published in
Journal of Neuroinflammation, March 2015
DOI 10.1186/s12974-015-0275-y
Pubmed ID
Authors

Ting Zhang, Xiaoli Gong, Guanzheng Hu, Xiaomin Wang

Abstract

Microglia are key players for the inflammatory responses in the central nervous system. Suppression of microglial activation and the resulting production of proinflammatory molecules are considered a promising strategy to alleviate the progression of neurodegenerative disorders. Triptolide was demonstrated as a potent anti-inflammatory compound both in vitro and in vivo. The present study explored potential signal pathways of triptolide in the lipopolysaccharide (LPS)-induced inflammatory response using primary rat microglial cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 33%
Student > Master 3 17%
Professor 1 6%
Student > Doctoral Student 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 5 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Medicine and Dentistry 2 11%
Neuroscience 2 11%
Biochemistry, Genetics and Molecular Biology 1 6%
Chemical Engineering 1 6%
Other 2 11%
Unknown 5 28%