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Sex differences in TGFB-β signaling with respect to age of onset and cognitive functioning in schizophrenia

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2015
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Title
Sex differences in TGFB-β signaling with respect to age of onset and cognitive functioning in schizophrenia
Published in
Neuropsychiatric Disease and Treatment, March 2015
DOI 10.2147/ndt.s74672
Pubmed ID
25784812
Authors

Lidia Karabon, Dorota Frydecka, Edyta Pawlak-Adamska, Anna Tomkiewicz, Paweł Sedlaczek, Andrzej Kiejna, Jan Aleksander Beszłej, Błażej Misiak

Abstract

There are studies showing that gene polymorphisms within the transforming growth factor-β (TGF-β) signaling constitute schizophrenia risk variants. However, the association between TGFB1 gene polymorphisms (+869T/C and +915G/C), TGF-β level with schizophrenia course, and its symptomatology together with cognitive functioning has not been investigated so far. We included 151 patients with schizophrenia and 279 healthy controls. Cognitive functioning was assessed using Rey Auditory Verbal Learning Test, Trail Making Test (TMT)-A and TMT-B, Verbal Fluency task, Stroop test, as well as selected subtests from the Wechsler Adults Intelligence Scale - Revised, Polish adaptation (WAIS-R-Pl): Digit Symbol Coding, Digit Span Forward and Backward, and Similarities. Additionally, serum TGF-β levels were measured in 88 schizophrenia patients and 88 healthy controls. Serum TGF-β level was significantly higher among patients with schizophrenia in comparison with healthy controls; however, the studied polymorphisms were not associated with TGF-β level in schizophrenia patients. Subjects carrying the +869T allele performed significantly worse in comparison with +869CC homozygotes on Stroop task, Verbal Fluency task and Digit Symbol Coding task. There was a significant difference in age of psychosis onset in female schizophrenia patients with respect to the TGFB1 +869T/C polymorphism. Additionally, adjustment for possible confounders revealed that there was a significant difference in cognitive performance on Digit Symbol Coding task with respect to the TGFB1 +869T/C polymorphism among female schizophrenia patients. Our results suggest that TGF-β signaling might be a valid link contributing to observed differences in age of onset and the level of cognitive decline between male and female schizophrenia patients.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 22%
Student > Master 10 19%
Student > Ph. D. Student 8 15%
Student > Doctoral Student 4 7%
Other 3 6%
Other 9 17%
Unknown 8 15%
Readers by discipline Count As %
Psychology 9 17%
Medicine and Dentistry 7 13%
Agricultural and Biological Sciences 6 11%
Biochemistry, Genetics and Molecular Biology 5 9%
Neuroscience 3 6%
Other 8 15%
Unknown 16 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2015.
All research outputs
#20,265,771
of 22,796,179 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,423
of 2,984 outputs
Outputs of similar age
#216,379
of 256,542 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#51
of 67 outputs
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So far Altmetric has tracked 2,984 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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