Title |
Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp.
|
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Published in |
Journal of Natural Products, March 2015
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DOI | 10.1021/acs.jnatprod.5b00095 |
Pubmed ID | |
Authors |
Zeinab G. Khalil, Ritesh Raju, Andrew M. Piggott, Angela A. Salim, Antje Blumenthal, Robert J. Capon |
Abstract |
Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 μM) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 μM) and a panel of human cancer cell lines (IC50 > 7.5 μM). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 μM) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Guérin. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Ghana | 1 | 2% |
Luxembourg | 1 | 2% |
Unknown | 55 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 16% |
Researcher | 7 | 12% |
Student > Doctoral Student | 5 | 9% |
Student > Postgraduate | 5 | 9% |
Student > Master | 5 | 9% |
Other | 8 | 14% |
Unknown | 18 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 8 | 14% |
Agricultural and Biological Sciences | 5 | 9% |
Nursing and Health Professions | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 7 | 12% |
Unknown | 21 | 37% |