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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multiplex Cytological Profiling Assay to Measure Diverse Cellular States
|
|---|---|
| Published in |
PLOS ONE, December 2013
|
| DOI | 10.1371/journal.pone.0080999 |
| Pubmed ID | |
| Authors |
Sigrun M. Gustafsdottir, Vebjorn Ljosa, Katherine L. Sokolnicki, J. Anthony Wilson, Deepika Walpita, Melissa M. Kemp, Kathleen Petri Seiler, Hyman A. Carrel, Todd R. Golub, Stuart L. Schreiber, Paul A. Clemons, Anne E. Carpenter, Alykhan F. Shamji |
| Abstract |
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling assay that "paints the cell" with as many fluorescent markers as possible without compromising our ability to extract rich, quantitative profiles in high throughput. The assay detects seven major cellular components. In a pilot screen of bioactive compounds, the assay detected a range of cellular phenotypes and it clustered compounds with similar annotated protein targets or chemical structure based on cytological profiles. The results demonstrate that the assay captures subtle patterns in the combination of morphological labels, thereby detecting the effects of chemical compounds even though their targets are not stained directly. This image-based assay provides an unbiased approach to characterize compound- and disease-associated cell states to support future probe discovery. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| Germany | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 307 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 92 | 29% |
| Student > Ph. D. Student | 60 | 19% |
| Student > Master | 28 | 9% |
| Student > Bachelor | 21 | 7% |
| Other | 13 | 4% |
| Other | 37 | 12% |
| Unknown | 61 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 71 | 23% |
| Biochemistry, Genetics and Molecular Biology | 63 | 20% |
| Chemistry | 41 | 13% |
| Medicine and Dentistry | 16 | 5% |
| Engineering | 12 | 4% |
| Other | 41 | 13% |
| Unknown | 68 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2023.
All research outputs
#2,637,943
of 24,228,883 outputs
Outputs from PLOS ONE
#33,040
of 208,500 outputs
Outputs of similar age
#30,568
of 316,966 outputs
Outputs of similar age from PLOS ONE
#849
of 5,045 outputs
Altmetric has tracked 24,228,883 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 208,500 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 5,045 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.