Title |
Perfusion CT Estimates Photosensitizer Uptake and Biodistribution in a Rabbit Orthotopic Pancreatic Cancer Model A Pilot Study
|
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Published in |
Academic Radiology, February 2015
|
DOI | 10.1016/j.acra.2014.12.014 |
Pubmed ID | |
Authors |
Jonathan T. Elliott, Kimberley S. Samkoe, Jason R. Gunn, Errol E. Stewart, Timothy B. Gardner, Kenneth M. Tichauer, Ting-Yim Lee, P. Jack Hoopes, Stephen P. Pereira, Tayyaba Hasan, Brian W. Pogue |
Abstract |
It was hypothesized that perfusion computed tomography (CT), blood flow (BF), blood volume (BV), and vascular permeability surface area (PS) product parameters would be predictive of therapeutic anticancer agent uptake in pancreatic cancer, facilitating image-guided interpretation of human treatments. The hypothesis was tested in an orthotopic rabbit model of pancreatic cancer, by establishing the model, imaging with endoscopic ultrasound (EUS) and contrast CT, and spatially comparing the perfusion maps to the ex vivo uptake values of the injected photosensitizer, verteporfin. |
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