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Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

Overview of attention for article published in Journal of Clinical Investigation, October 2011
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Title
Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis
Published in
Journal of Clinical Investigation, October 2011
DOI 10.1172/jci46458
Pubmed ID
Authors

Shreeram Akilesh, Hani Suleiman, Haiyang Yu, M. Christine Stander, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollak, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw

Abstract

The specialized epithelial cell of the kidney, the podocyte, has a complex actin-based cytoskeleton. Dynamic regulation of this cytoskeleton is required for efficient barrier function of the kidney. Podocytes are a useful cell type to study the control of the actin cytoskeleton in vivo, because disruption of components of the cytoskeleton results in podocyte damage, cell loss, and a prototypic injury response called focal segmental glomerulosclerosis (FSGS). Searching for actin regulatory proteins that are expressed in podocytes, we identified a RhoA-activated Rac1 GTPase-activating protein (Rac1-GAP), Arhgap24, that was upregulated in podocytes as they differentiated, both in vitro and in vivo. Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics. Consistent with a role for Arhgap24 in normal podocyte functioning in vivo, sequencing of the ARHGAP24 gene in patients with FSGS identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS. Thus, Arhgap24 contributes to the careful balancing of RhoA and Rac1 signaling in podocytes, the disruption of which may lead to kidney disease.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Denmark 1 1%
Japan 1 1%
United States 1 1%
Unknown 81 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 29%
Student > Ph. D. Student 18 21%
Other 8 9%
Student > Doctoral Student 7 8%
Professor > Associate Professor 7 8%
Other 20 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 38%
Medicine and Dentistry 21 25%
Biochemistry, Genetics and Molecular Biology 20 24%
Unspecified 5 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 3 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2011.
All research outputs
#7,794,416
of 12,423,550 outputs
Outputs from Journal of Clinical Investigation
#11,990
of 13,119 outputs
Outputs of similar age
#58,109
of 95,317 outputs
Outputs of similar age from Journal of Clinical Investigation
#59
of 86 outputs
Altmetric has tracked 12,423,550 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,119 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,317 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.