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N-Acetylcysteine Increases the Frequency of Bone Marrow Pro-B/Pre-B Cells, but Does Not Reverse Cigarette Smoking-Induced Loss of This Subset

Overview of attention for article published in PLOS ONE, September 2011
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Title
N-Acetylcysteine Increases the Frequency of Bone Marrow Pro-B/Pre-B Cells, but Does Not Reverse Cigarette Smoking-Induced Loss of This Subset
Published in
PLOS ONE, September 2011
DOI 10.1371/journal.pone.0024804
Pubmed ID
Authors

Victoria L. Palmer, Michele D. Kassmeier, James Willcockson, Mohammed P. Akhter, Diane M. Cullen, Patrick C. Swanson

Abstract

We previously showed that mice exposed to cigarette smoke for three weeks exhibit loss of bone marrow B cells at the Pro-B-to-pre-B cell transition, but the reason for this is unclear. The antioxidant N-acetylcysteine (NAC), a glutathione precursor, has been used as a chemopreventive agent to reduce adverse effects of cigarette smoke exposure on lung function. Here we determined whether smoke exposure impairs B cell development by inducing cell cycle arrest or apoptosis, and whether NAC treatment prevents smoking-induced loss of developing B cells.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 17%
Student > Ph. D. Student 2 17%
Student > Master 2 17%
Other 1 8%
Student > Bachelor 1 8%
Other 3 25%
Unknown 1 8%
Readers by discipline Count As %
Immunology and Microbiology 4 33%
Agricultural and Biological Sciences 3 25%
Medicine and Dentistry 2 17%
Biochemistry, Genetics and Molecular Biology 1 8%
Unknown 2 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2011.
All research outputs
#15,236,094
of 22,653,392 outputs
Outputs from PLOS ONE
#129,679
of 193,422 outputs
Outputs of similar age
#79,828
of 114,473 outputs
Outputs of similar age from PLOS ONE
#1,630
of 2,520 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,422 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,473 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,520 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.