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Comparative genome analysis of Pediococcus damnosus LMG 28219, a strain well-adapted to the beer environment

Overview of attention for article published in BMC Genomics, April 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

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19 tweeters
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1 Wikipedia page

Citations

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10 Dimensions

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40 Mendeley
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Title
Comparative genome analysis of Pediococcus damnosus LMG 28219, a strain well-adapted to the beer environment
Published in
BMC Genomics, April 2015
DOI 10.1186/s12864-015-1438-z
Pubmed ID
Authors

Isabel Snauwaert, Pieter Stragier, Luc De Vuyst, Peter Vandamme

Abstract

Pediococcus damnosus LMG 28219 is a lactic acid bacterium dominating the maturation phase of Flemish acid beer productions. It proved to be capable of growing in beer, thereby resisting this environment, which is unfavorable for microbial growth. The molecular mechanisms underlying its metabolic capabilities and niche adaptations were unknown up to now. In the present study, whole-genome sequencing and comparative genome analysis were used to investigate this strain's mechanisms to reside in the beer niche, with special focus on not only stress and hop resistances but also folate biosynthesis and exopolysaccharide (EPS) production. The draft genome sequence of P. damnosus LMG 28219 harbored 183 contigs, including an intact prophage region and several coding sequences involved in plasmid replication. The annotation of 2178 coding sequences revealed the presence of many transporters and transcriptional regulators and several genes involved in oxidative stress response, hop resistance, de novo folate biosynthesis, and EPS production. Comparative genome analysis of P. damnosus LMG 28219 with Pediococcus claussenii ATCC BAA-344(T) (beer origin) and Pediococcus pentosaceus ATCC 25745 (plant origin) revealed that various hop resistance genes and genes involved in de novo folate biosynthesis were unique to the strains isolated from beer. This contrasted with the genes related to osmotic stress responses, which were shared between the strains compared. Furthermore, transcriptional regulators were enriched in the genomes of bacteria capable of growth in beer, suggesting that those cause rapid up- or down-regulation of gene expression. Genome sequence analysis of P. damnosus LMG 28219 provided insights into the underlying mechanisms of its adaptation to the beer niche. The results presented will enable analysis of the transcriptome and proteome of P. damnosus LMG 28219, which will result in additional knowledge on its metabolic activities.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
India 1 3%
Unknown 37 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Researcher 7 18%
Student > Doctoral Student 5 13%
Student > Master 5 13%
Other 4 10%
Other 8 20%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 53%
Biochemistry, Genetics and Molecular Biology 6 15%
Environmental Science 3 8%
Immunology and Microbiology 3 8%
Veterinary Science and Veterinary Medicine 1 3%
Other 3 8%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2019.
All research outputs
#1,123,680
of 14,110,318 outputs
Outputs from BMC Genomics
#424
of 8,296 outputs
Outputs of similar age
#23,154
of 223,962 outputs
Outputs of similar age from BMC Genomics
#1
of 1 outputs
Altmetric has tracked 14,110,318 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,296 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,962 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them