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Attention Score in Context
| Title |
Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0025735 |
| Pubmed ID | |
| Authors |
Ji-Song Guan, Susan C. Su, Jun Gao, Nadine Joseph, Zhigang Xie, Ying Zhou, Omer Durak, Lei Zhang, J. Julius Zhu, Karl R. Clauser, Steven A. Carr, Li-Huei Tsai |
| Abstract |
Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of synaptic plasticity in cultured neurons. Surprisingly, we found that Cdk5 loss of function in hippocampal circuits results in severe impairments in memory formation and retrieval. Moreover, Cdk5 loss of function in the hippocampus disrupts cAMP signaling due to an aberrant increase in phosphodiesterase (PDE) proteins. Dysregulation of cAMP is associated with defective CREB phosphorylation and disrupted composition of synaptic proteins in Cdk5-deficient mice. Rolipram, a PDE4 inhibitor that prevents cAMP depletion, restores synaptic plasticity and memory formation in Cdk5-deficient mice. Collectively, our results demonstrate a critical role for Cdk5 in the regulation of cAMP-mediated hippocampal functions essential for synaptic plasticity and memory formation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| United States | 1 | 1% |
| Kazakhstan | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 20% |
| Student > Ph. D. Student | 14 | 16% |
| Student > Master | 8 | 9% |
| Student > Bachelor | 7 | 8% |
| Student > Doctoral Student | 7 | 8% |
| Other | 17 | 19% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 33% |
| Neuroscience | 18 | 20% |
| Medicine and Dentistry | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Computer Science | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 17 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2011.
All research outputs
#20,147,309
of 22,653,392 outputs
Outputs from PLOS ONE
#172,535
of 193,422 outputs
Outputs of similar age
#121,035
of 131,667 outputs
Outputs of similar age from PLOS ONE
#2,374
of 2,569 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,422 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 131,667 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,569 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.