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| Title |
Effect of eye NGF administration on two animal models of retinal ganglion cells degeneration.
|
|---|---|
| Published in |
Annali dell'Istituto Superiore di Sanità, January 2011
|
| DOI | 10.4415/ann_11_03_08 |
| Pubmed ID | |
| Authors |
Valeria Colafrancesco, Marco Coassin, Simona Rossi, Luigi Aloe |
| Abstract |
The aim of this study was to investigate the effect of nerve growth factor (NGF) administration on retinal ganglion cells (RGCs) in experimentally induced glaucoma (GL) and diabetic retinopathy (DR). GL was induced in adult rats by injection of hypertonic saline into the episcleral vein of the eye and diabetes (DT) was induced by administration of streptozoticin. Control and experimental rats were treated daily with either ocular application of NGF or vehicle solution. We found that both animal models present a progressive degeneration of RGCs and changing NGF and VEGF levels in the retina and optic nerve. We then proved that NGF eye drop administration exerts a protective effect on these models of retinal degeneration. In brief, our findings indicate that NGF can play a protective role against RGC degeneration occurring in GL and DR and suggest that ocular NGF administration might be an effective pharmacological approach. |
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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2011.
All research outputs
#22,764,772
of 25,377,790 outputs
Outputs from Annali dell'Istituto Superiore di Sanità
#231
of 279 outputs
Outputs of similar age
#180,604
of 190,502 outputs
Outputs of similar age from Annali dell'Istituto Superiore di Sanità
#20
of 20 outputs
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So far Altmetric has tracked 279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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