↓ Skip to main content

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

Overview of attention for article published in Brain, Behavior & Immunity, August 2015
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
2 news outlets
twitter
34 tweeters
patent
4 patents
facebook
16 Facebook pages
video
1 video uploader

Citations

dimensions_citation
507 Dimensions

Readers on

mendeley
873 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
Published in
Brain, Behavior & Immunity, August 2015
DOI 10.1016/j.bbi.2015.04.004
Pubmed ID
Authors

Lieve Desbonnet, Gerard Clarke, Alexander Traplin, Orla O’Sullivan, Fiona Crispie, Rachel D. Moloney, Paul D. Cotter, Timothy G. Dinan, John F. Cryan

Abstract

There is growing appreciation for the importance of bacteria in shaping brain development and behaviour. Adolescence and early adulthood are crucial developmental periods during which exposure to harmful environmental factors can have a permanent impact on brain function. Such environmental factors include perturbations of the gut bacteria that may affect gut-brain communication, altering the trajectory of brain development, and increasing vulnerability to psychiatric disorders. Here we assess the effects of gut bacterial depletion from weaning onwards on adult cognitive, social and emotional behaviours and markers of gut-brain axis dysfunction in mice. Mice were treated with a combination of antibiotics from weaning onwards and effects on behaviours and potential brain-gut axis neuromodulators (tryptophan, monoamines, and neuropeptides) and BDNF expression were assessed in adulthood. Antibiotic-treatment depleted and restructured gut microbiota composition of caecal contents and decreased spleen weights in adulthood. Depletion of the gut microbiota from weaning onwards reduced anxiety, induced cognitive deficits, altered dynamics of the tryptophan metabolic pathway, and significantly reduced BDNF, oxytocin and vasopressin expression in the adult brain. Microbiota depletion from weaning onwards by means of chronic treatment with antibiotics in mice impacts on anxiety and cognitive behaviours as well as key neuromodulators of gut-brain communication in a manner that is similar to that reported in germ-free mice. This model may represent a more amenable alternative for germ-free mice in the assessment of microbiota modulation of behaviour. Finally, these data suggest that despite the presence of a normal gut microbiome in early postnatal life, reduced abundance and diversity of the gut microbiota from weaning influences adult behaviours and key neuromodulators of the microbiota-gut-brain axis suggesting that dysregulation of this axis in the post-weaning period may contribute to the pathogenesis of disorders associated with altered anxiety and cognition.

Twitter Demographics

The data shown below were collected from the profiles of 34 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 873 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Portugal 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Belgium 1 <1%
France 1 <1%
Spain 1 <1%
Denmark 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 862 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 158 18%
Student > Ph. D. Student 138 16%
Student > Master 135 15%
Researcher 101 12%
Student > Doctoral Student 53 6%
Other 115 13%
Unknown 173 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 142 16%
Neuroscience 123 14%
Biochemistry, Genetics and Molecular Biology 108 12%
Medicine and Dentistry 92 11%
Psychology 56 6%
Other 145 17%
Unknown 207 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2022.
All research outputs
#813,874
of 23,543,207 outputs
Outputs from Brain, Behavior & Immunity
#259
of 3,186 outputs
Outputs of similar age
#10,777
of 265,649 outputs
Outputs of similar age from Brain, Behavior & Immunity
#5
of 52 outputs
Altmetric has tracked 23,543,207 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,649 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.