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Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.

Overview of attention for article published in Molecular Neurodegeneration, September 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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1 tweeter
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2 Facebook pages

Citations

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51 Dimensions

Readers on

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72 Mendeley
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Title
Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.
Published in
Molecular Neurodegeneration, September 2011
DOI 10.1186/1750-1326-6-65
Pubmed ID
Abstract

Memory deficits in Alzheimer's disease (AD) manifest together with the loss of synapses caused by the disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines. However, the underlying molecular mechanisms remain elusive. Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Aβ) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Aβ contributes to ProSAP/Shank platform malformation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Netherlands 1 1%
Unknown 69 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 24%
Researcher 17 24%
Student > Doctoral Student 9 13%
Student > Master 9 13%
Student > Bachelor 5 7%
Other 9 13%
Unknown 6 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 32%
Neuroscience 14 19%
Medicine and Dentistry 8 11%
Biochemistry, Genetics and Molecular Biology 7 10%
Social Sciences 3 4%
Other 10 14%
Unknown 7 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2011.
All research outputs
#1,722,409
of 3,633,792 outputs
Outputs from Molecular Neurodegeneration
#94
of 199 outputs
Outputs of similar age
#19,680
of 62,963 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 11 outputs
Altmetric has tracked 3,633,792 research outputs across all sources so far. This one has received more attention than most of these and is in the 50th percentile.
So far Altmetric has tracked 199 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.