Title |
Designing and conducting randomized controlled trials in palliative care: A summary of discussions from the 2010 clinical research forum of the Australian Palliative Care Clinical Studies Collaborative
|
---|---|
Published in |
Palliative Medicine, August 2011
|
DOI | 10.1177/0269216311417036 |
Pubmed ID | |
Authors |
Tania M Shelby-James, Janet Hardy, Meera Agar, Patsy Yates, Geoff Mitchell, Christine Sanderson, Tim Luckett, Amy P Abernethy, David C Currow |
Abstract |
Rigorous clinical research in palliative care is challenging but achievable. Trial participants are likely to have deteriorating performance status, co-morbidities and progressive disease. It is difficult to recruit patients, and attrition unrelated to the intervention being trialled is high. The aim of this paper is to highlight practical considerations from a forum held to discuss these issues by active palliative care clinical researchers. To date, the Australian Palliative Care Clinical Studies Collaborative (PaCCSC) has randomized more than 500 participants across 12 sites in 8 Phase III studies. Insights from the 2010 clinical research forum of the PaCCSC are reported. All active Australian researchers in palliative care were invited to present their current research and address three specific questions: (1) What has worked well? (2) What didn't work well? and (3) How should the research be done differently next time? Fourteen studies were presented, including six double-blind, randomized, controlled, multi-site trials run by the PaCCSC. Key recommendations are reported, including guidance on design; methodologies; and strategies for maximizing recruitment and retention. These recommendations will help to inform future trial design and conduct in palliative care. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 25% |
United States | 3 | 19% |
Australia | 2 | 13% |
Zimbabwe | 1 | 6% |
Canada | 1 | 6% |
Peru | 1 | 6% |
Unknown | 4 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 69% |
Scientists | 2 | 13% |
Science communicators (journalists, bloggers, editors) | 2 | 13% |
Unknown | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 4% |
United States | 2 | 4% |
Spain | 1 | 2% |
Sudan | 1 | 2% |
Unknown | 48 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 22% |
Other | 7 | 13% |
Researcher | 7 | 13% |
Student > Postgraduate | 6 | 11% |
Student > Ph. D. Student | 6 | 11% |
Other | 11 | 20% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 59% |
Nursing and Health Professions | 7 | 13% |
Social Sciences | 3 | 6% |
Business, Management and Accounting | 2 | 4% |
Computer Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 7 | 13% |