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Mendeley readers
Attention Score in Context
| Title |
Phage-Antibiotic Synergy (PAS): β-Lactam and Quinolone Antibiotics Stimulate Virulent Phage Growth
|
|---|---|
| Published in |
PLOS ONE, August 2007
|
| DOI | 10.1371/journal.pone.0000799 |
| Pubmed ID | |
| Authors |
André M. Comeau, Françoise Tétart, Sabrina N. Trojet, Marie-Françoise Prère, H.M. Krisch |
| Abstract |
Although the multiplication of bacteriophages (phages) has a substantial impact on the biosphere, comparatively little is known about how the external environment affects phage production. Here we report that sub-lethal concentrations of certain antibiotics can substantially stimulate the host bacterial cell's production of some virulent phage. For example, a low dosage of cefotaxime, a cephalosporin, increased an uropathogenic Escherichia coli strain's production of the phage PhiMFP by more than 7-fold. We name this phenomenon Phage-Antibiotic Synergy (PAS). A related effect was observed in diverse host-phage systems, including the T4-like phages, with beta-lactam and quinolone antibiotics, as well as mitomycin C. A common characteristic of these antibiotics is that they inhibit bacterial cell division and trigger the SOS system. We therefore examined the PAS effect within the context of the bacterial SOS and filamentation responses. We found that the PAS effect appears SOS-independent and is primarily a consequence of cellular filamentation; it is mimicked by cells that constitutively filament. The fact that completely unrelated phages manifest this phenomenon suggests that it confers an important and general advantage to the phages. |
Mendeley readers
The data shown below were compiled from readership statistics for 410 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Switzerland | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 399 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 69 | 17% |
| Student > Ph. D. Student | 64 | 16% |
| Student > Master | 52 | 13% |
| Researcher | 37 | 9% |
| Student > Doctoral Student | 17 | 4% |
| Other | 46 | 11% |
| Unknown | 125 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 87 | 21% |
| Biochemistry, Genetics and Molecular Biology | 68 | 17% |
| Immunology and Microbiology | 57 | 14% |
| Medicine and Dentistry | 14 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 2% |
| Other | 39 | 10% |
| Unknown | 135 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2022.
All research outputs
#2,002,233
of 23,341,064 outputs
Outputs from PLOS ONE
#25,465
of 199,618 outputs
Outputs of similar age
#4,138
of 69,531 outputs
Outputs of similar age from PLOS ONE
#41
of 227 outputs
Altmetric has tracked 23,341,064 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 199,618 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,531 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 227 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.