↓ Skip to main content

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

Overview of attention for article published in Nature Communications, April 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

news
1 news outlet
twitter
11 tweeters

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
95 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation
Published in
Nature Communications, April 2015
DOI 10.1038/ncomms7840
Pubmed ID
Authors

Marianna Papaspyridonos, Irina Matei, Yujie Huang, Maria do Rosario Andre, Helene Brazier-Mitouart, Janelle C. Waite, April S. Chan, Julie Kalter, Ilyssa Ramos, Qi Wu, Caitlin Williams, Jedd D. Wolchok, Paul B. Chapman, Hector Peinado, Niroshana Anandasabapathy, Allyson J. Ocean, Rosandra N. Kaplan, Jeffrey P. Greenfield, Jacqueline Bromberg, Dimitris Skokos, David Lyden

Abstract

A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors, such as TGFβ, is responsible for the switch from dendritic cell (DC) differentiation to myeloid-derived suppressor cell expansion during tumour progression. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumour-derived factors re-creates it. Id1 overexpression leads to systemic immunosuppression by downregulation of key molecules involved in DC differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression. Furthermore, advanced melanoma patients have increased plasma TGFβ levels and express higher levels of ID1 in myeloid peripheral blood cells. This study reveals a critical role for Id1 in suppressing the anti-tumour immune response during tumour progression and metastasis.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Germany 1 1%
United Kingdom 1 1%
United States 1 1%
Luxembourg 1 1%
Unknown 90 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 22%
Student > Master 17 18%
Researcher 17 18%
Student > Bachelor 9 9%
Other 6 6%
Other 13 14%
Unknown 12 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 28%
Biochemistry, Genetics and Molecular Biology 18 19%
Medicine and Dentistry 16 17%
Immunology and Microbiology 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 8 8%
Unknown 16 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2015.
All research outputs
#1,105,371
of 14,046,825 outputs
Outputs from Nature Communications
#12,201
of 25,854 outputs
Outputs of similar age
#23,094
of 229,499 outputs
Outputs of similar age from Nature Communications
#281
of 644 outputs
Altmetric has tracked 14,046,825 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,854 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.9. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 644 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.