↓ Skip to main content

Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women

Overview of attention for article published in Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, April 2018
Altmetric Badge

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
104 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women
Published in
Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, April 2018
DOI 10.1055/s-0038-1642632
Pubmed ID
Authors

Willian Sales, Iramar Nascimento, Guilherme Dienstmann, Matheus Souza, Grazielle Silva, Jean Silva

Abstract

 To assess the effectiveness of metformin in the incidence of gestational diabetes mellitus (GDM) in obese pregnant women attending a public maternity hospital in Joinville, Santa Catarina, Brazil.  Randomized clinical trial including obese pregnant women with a body mass index (BMI) ≥ 30 kg/m2, divided into two groups (control and metformin). Both groups received guidance regarding diet and physical exercise. The participants were assessed at two moments, the first at enrollment (gestational age ≤ 20) and the second at gestational weeks 24-28. The outcomes assessed were BMI and gestational diabetes mellitus (GDM) diagnosis. The data distribution was assessed with the Friedman test. For all the analytical models, the p-values were considered significant when lower than 0.05. The absolute risk reduction was also estimated.  Overall, 164 pregnant women were assessed and further divided into 82 participants per group. No significant difference was observed in BMI variation between the control and metformin groups (0.9 ± 1.2 versus 1.0 ± 0.9, respectively, p = 0.63). Gestational diabetes mellitus was diagnosed in 15.9% (n = 13) of the patients allocated to the metformin group and 19.5% (n = 16) of those in the control group (p = 0.683). The absolute risk reduction was 3.6 (95% confidence interval 8.0-15.32) in the group treated with metformin, which was not significant.  Metformin was not effective in reducing BMI and preventing GDM in obese pregnant women.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 104 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 15%
Student > Master 15 14%
Student > Ph. D. Student 6 6%
Student > Postgraduate 5 5%
Student > Doctoral Student 4 4%
Other 14 13%
Unknown 44 42%
Readers by discipline Count As %
Medicine and Dentistry 20 19%
Nursing and Health Professions 18 17%
Biochemistry, Genetics and Molecular Biology 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Psychology 4 4%
Other 7 7%
Unknown 45 43%