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X Demographics
Mendeley readers
Attention Score in Context
| Title |
An alternative pluripotent state confers interspecies chimaeric competency
|
|---|---|
| Published in |
Nature, May 2015
|
| DOI | 10.1038/nature14413 |
| Pubmed ID | |
| Authors |
Jun Wu, Daiji Okamura, Mo Li, Keiichiro Suzuki, Chongyuan Luo, Li Ma, Yupeng He, Zhongwei Li, Chris Benner, Isao Tamura, Marie N. Krause, Joseph R. Nery, Tingting Du, Zhuzhu Zhang, Tomoaki Hishida, Yuta Takahashi, Emi Aizawa, Na Young Kim, Jeronimo Lajara, Pedro Guillen, Josep M. Campistol, Concepcion Rodriguez Esteban, Pablo J. Ross, Alan Saghatelian, Bing Ren, Joseph R. Ecker, Juan Carlos Izpisua Belmonte |
| Abstract |
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution. |
X Demographics
The data shown below were collected from the profiles of 62 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 23% |
| Japan | 6 | 10% |
| United Kingdom | 5 | 8% |
| Italy | 2 | 3% |
| Australia | 2 | 3% |
| Spain | 2 | 3% |
| Mexico | 1 | 2% |
| Comoros | 1 | 2% |
| France | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 23 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 38 | 61% |
| Scientists | 19 | 31% |
| Science communicators (journalists, bloggers, editors) | 5 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 584 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 2% |
| Japan | 6 | 1% |
| Spain | 4 | <1% |
| France | 3 | <1% |
| Netherlands | 2 | <1% |
| China | 1 | <1% |
| Australia | 1 | <1% |
| Singapore | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 555 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 133 | 23% |
| Student > Ph. D. Student | 129 | 22% |
| Student > Master | 53 | 9% |
| Student > Bachelor | 47 | 8% |
| Professor > Associate Professor | 38 | 7% |
| Other | 108 | 18% |
| Unknown | 76 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 234 | 40% |
| Biochemistry, Genetics and Molecular Biology | 159 | 27% |
| Medicine and Dentistry | 38 | 7% |
| Engineering | 12 | 2% |
| Neuroscience | 12 | 2% |
| Other | 35 | 6% |
| Unknown | 94 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 343. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#97,562
of 25,784,004 outputs
Outputs from Nature
#6,755
of 98,755 outputs
Outputs of similar age
#927
of 279,968 outputs
Outputs of similar age from Nature
#117
of 1,022 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,755 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,022 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.