Title |
Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report
|
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Published in |
BMC Cancer, May 2015
|
DOI | 10.1186/s12885-015-1391-x |
Pubmed ID | |
Authors |
Dae Won Kim, Edelyn Barcena, Urvi N Mehta, Michelle L Rohlfs, Ashok J Kumar, Marta Penas-Prado, Kevin B Kim |
Abstract |
Leptomeningeal metastasis of melanoma is a devastating complication with a grave prognosis, and there are no known effective standard treatments. Although selective BRAF inhibitors have demonstrated a significant clinical activity in patients with metastatic melanoma harboring a BRAF mutation, the clinical benefit of BRAF inhibitor-based therapy in leptomeningeal disease is not clear. We present a case of prolonged survival of a patient with BRAF V600E-mutant leptomeningeal disease who was treated with vemurafenib followed by whole brain radiation and a combination of dabrafenib and trametinib. Both vemurafenib and the sequential treatment of radiation and dabrafenib/trametinib led to regression of the leptomeningeal disease, and the patient survived for 19 months after the diagnosis of the leptomeningeal disease. This case suggests a possible clinically meaningful benefit of BRAF inhibitor-based therapy and a need for close investigation of this therapeutic approach in patients with this devastating disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 24% |
Student > Bachelor | 4 | 14% |
Student > Ph. D. Student | 3 | 10% |
Student > Master | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Other | 2 | 7% |
Unknown | 8 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 41% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Unknown | 11 | 38% |