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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Expression of the vault RNA protects cells from undergoing apoptosis
|
|---|---|
| Published in |
Nature Communications, May 2015
|
| DOI | 10.1038/ncomms8030 |
| Pubmed ID | |
| Authors |
Melanie Amort, Birgit Nachbauer, Selma Tuzlak, Arnd Kieser, Aloys Schepers, Andreas Villunger, Norbert Polacek |
| Abstract |
Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent EBV-encoded proteins in B cells and identify the latent membrane protein 1 (LMP1) as trigger for vtRNA upregulation. Ectopic expression of vtRNA1-1, but not of the other vtRNA paralogues, results in an improved viral establishment and reduced apoptosis, a function located in the central domain of vtRNA1-1. Knockdown of the major vault protein has no effect on these phenotypes revealing that vtRNA1-1 and not the vault complex contributes to general cell death resistance. This study describes a NF-κB-mediated role of the non-coding vtRNA1-1 in inhibiting both the extrinsic and intrinsic apoptotic pathways. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 2% |
| United States | 2 | 2% |
| Norway | 1 | <1% |
| Denmark | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 125 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 29% |
| Researcher | 24 | 18% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 6 | 5% |
| Other | 16 | 12% |
| Unknown | 23 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 36% |
| Agricultural and Biological Sciences | 29 | 22% |
| Medicine and Dentistry | 9 | 7% |
| Immunology and Microbiology | 5 | 4% |
| Engineering | 4 | 3% |
| Other | 12 | 9% |
| Unknown | 25 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2023.
All research outputs
#2,567,632
of 24,792,414 outputs
Outputs from Nature Communications
#28,925
of 53,949 outputs
Outputs of similar age
#32,161
of 269,787 outputs
Outputs of similar age from Nature Communications
#317
of 752 outputs
Altmetric has tracked 24,792,414 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 53,949 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.0. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,787 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 752 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.