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Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma

Overview of attention for article published in Revista Brasileira de Psiquiatria, July 2010
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Title
Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma
Published in
Revista Brasileira de Psiquiatria, July 2010
DOI 10.1590/s1516-44462010000200015
Pubmed ID
Authors

Gilberto Paz-Filho, Julio Licinio, Ma-Li Wong

Abstract

To describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease. A review of the literature based on the PubMed database. Depression and cardiovascular disease are both highly prevalent. Several studies have shown that the two are closely related. They share common pathophysiological etiologies or co-morbidities, such as alterations in the hypothalamic-pituitary axis, cardiac rhythm disturbances, and hemorheologic, inflammatory and serotoninergic changes. Furthermore, antidepressant treatment is associated with worse cardiac outcomes (in case of tricyclics), which are not observed with selective serotonin reuptake inhibitors. Although there is a strong association between depression and cardiovascular disease, it is still unclear whether depression is actually a causal factor for CVD, or is a mere consequence, or whether both conditions share a common pathophysiological etiology. Nevertheless, both conditions must be treated concomitantly. Drugs other than tricyclics must be used, when needed, to treat the underlying depression and not as mere prophylactic of cardiac outcomes.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 16%
Student > Doctoral Student 7 12%
Student > Bachelor 6 11%
Student > Ph. D. Student 5 9%
Student > Master 4 7%
Other 11 19%
Unknown 15 26%
Readers by discipline Count As %
Medicine and Dentistry 17 30%
Agricultural and Biological Sciences 7 12%
Psychology 4 7%
Nursing and Health Professions 4 7%
Social Sciences 3 5%
Other 7 12%
Unknown 15 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2015.
All research outputs
#17,836,891
of 26,128,906 outputs
Outputs from Revista Brasileira de Psiquiatria
#538
of 915 outputs
Outputs of similar age
#88,703
of 108,136 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#11
of 15 outputs
Altmetric has tracked 26,128,906 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 915 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.