Title |
Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients
|
---|---|
Published in |
Memórias do Instituto Oswaldo Cruz, April 2015
|
DOI | 10.1590/0074-02760140377 |
Pubmed ID | |
Authors |
Nora A Fierro, Karina González-Aldaco, Rafael Torres-Valadez, Maria E Trujillo-Trujillo, Sonia Roman, Jorge L Trujillo-Ochoa, Arturo Panduro/ |
Abstract |
The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggeststhat cytokine profiles may predict disease outcome during HCV infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 3% |
Unknown | 30 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 19% |
Student > Doctoral Student | 4 | 13% |
Student > Bachelor | 4 | 13% |
Student > Postgraduate | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Other | 6 | 19% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 29% |
Agricultural and Biological Sciences | 7 | 23% |
Medicine and Dentistry | 7 | 23% |
Immunology and Microbiology | 2 | 6% |
Materials Science | 1 | 3% |
Other | 0 | 0% |
Unknown | 5 | 16% |