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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence
|
|---|---|
| Published in |
Clinical Epigenetics, April 2015
|
| DOI | 10.1186/s13148-015-0055-7 |
| Pubmed ID | |
| Authors |
Adrian Ruiz-Hernandez, Chin-Chi Kuo, Pilar Rentero-Garrido, Wan-Yee Tang, Josep Redon, Jose M Ordovas, Ana Navas-Acien, Maria Tellez-Plaza |
| Abstract |
Current evidence supports the notion that environmental exposures are associated with DNA-methylation and expression changes that can impact human health. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between environmental chemicals with DNA methylation levels in adults. After excluding arsenic, recently evaluated in a systematic review, we identified a total of 17 articles (6 on cadmium, 4 on lead, 2 on mercury, 1 on nickel, 1 on antimony, 1 on tungsten, 5 on persistent organic pollutants and perfluorinated compounds, 1 on bisphenol A, and 3 on polycyclic aromatic hydrocarbons). The selected articles reported quantitative methods to determine DNA methylation including immunocolorimetric assays for total content of genomic DNA methylation, and microarray technologies, methylation-specific quantitative PCR, Luminometric Methylation Assay (LUMA), and bisulfite pyrosequencing for DNA methylation content of genomic sites such as gene promoters, LINE-1, Alu elements, and others. Considering consistency, temporality, strength, dose-response relationship, and biological plausibility, we concluded that the current evidence is not sufficient to provide inference because differences across studies and limited samples sizes make it difficult to compare across studies and to evaluate sources of heterogeneity. Important questions for future research include the need for larger and longitudinal studies, the validation of findings, and the systematic evaluation of the dose-response relationships. Future studies should also consider the evaluation of epigenetic marks recently in the research spotlight such as DNA hydroxymethylation and the role of underlying genetic variants. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 219 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 20% |
| Researcher | 33 | 15% |
| Student > Master | 23 | 10% |
| Student > Bachelor | 21 | 9% |
| Other | 13 | 6% |
| Other | 39 | 17% |
| Unknown | 52 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 47 | 21% |
| Medicine and Dentistry | 35 | 16% |
| Agricultural and Biological Sciences | 33 | 15% |
| Environmental Science | 15 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 22 | 10% |
| Unknown | 67 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2018.
All research outputs
#1,346,588
of 23,815,455 outputs
Outputs from Clinical Epigenetics
#62
of 1,328 outputs
Outputs of similar age
#17,638
of 265,803 outputs
Outputs of similar age from Clinical Epigenetics
#3
of 34 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,328 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,803 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.