↓ Skip to main content

Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study

Overview of attention for article published in Brazilian Journal of Anesthesiology, June 2014
Altmetric Badge

Citations

dimensions_citation
121 Dimensions

Readers on

mendeley
230 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study
Published in
Brazilian Journal of Anesthesiology, June 2014
DOI 10.1016/j.bjane.2014.05.001
Pubmed ID
Authors

Mefkur Bakan, Tarik Umutoglu, Ufuk Topuz, Harun Uysal, Mehmet Bayram, Huseyin Kadioglu, Ziya Salihoglu

Abstract

Intraoperative use of opioids may be associated with postoperative hyperalgesia and increased analgesic consumption. Side effects due to perioperative use of opioids, such as postoperative nausea and vomiting may delay discharge. We hypothesized that total intravenous anesthesia consisting of lidocaine and dexmedetomidine as an opioid substitute may be an alternative technique for laparoscopic cholecystectomy and would be associated with lower fentanyl requirements in the postoperative period and less incidence of postoperative nausea and vomiting. 80 Anesthesiologists I-II adults were scheduled for elective laparoscopic cholecystectomy. Patients were randomly allocated into two groups to have either opioid-free anesthesia with dexmedetomidine, lidocaine, and propofol infusions (Group DL) or opioid-based anesthesia with remifentanil, and propofol infusions (Group RF). All patients received a standard multimodal analgesia regimen. A patient controlled analgesia device was set to deliver IV fentanyl for 6h after surgery. The primary outcome variable was postoperative fentanyl consumption. Fentanyl consumption at postoperative 2nd hour was statistically significantly less in Group DL, compared with Group RF, which were 75±59μg and 120±94μg respectively, while it was comparable at postoperative 6th hour. During anesthesia, there were more hypotensive events in Group RF, while there were more hypertensive events in Group DL, which were both statistically significant. Despite higher recovery times, Group DL had significantly lower pain scores, rescue analgesic and ondansetron need. Opioid-free anesthesia with dexmedetomidine, lidocaine and propofol infusions may be an alternative technique for laparoscopic cholecystectomy especially in patients with high risk for postoperative nausea and vomiting.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 230 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 <1%
Romania 1 <1%
Brazil 1 <1%
Unknown 227 99%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 24 10%
Student > Bachelor 24 10%
Other 23 10%
Student > Postgraduate 20 9%
Researcher 16 7%
Other 36 16%
Unknown 87 38%
Readers by discipline Count As %
Medicine and Dentistry 100 43%
Nursing and Health Professions 10 4%
Veterinary Science and Veterinary Medicine 7 3%
Agricultural and Biological Sciences 6 3%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 12 5%
Unknown 90 39%