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EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED WOMEN

Overview of attention for article published in Revista do Instituto de Medicina Tropical de São Paulo, April 2015
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Title
EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED WOMEN
Published in
Revista do Instituto de Medicina Tropical de São Paulo, April 2015
DOI 10.1590/s0036-46652015000200012
Pubmed ID
Authors

Silvia de Souza Dantas ALCZUK, Patrícia de Souza BONFIM-MENDONÇA, Sheila Cristina ROCHA-BRISCHILIARI, Cristiane Suemi SHINOBU-MESQUITA, Helen Priscilla Rodrigues MARTINS, Fabrícia GIMENES, André Luelsdorf Pimenta de ABREU, Maria Dalva de Barros CARVALHO, Sandra Marisa PELLOSO, Terezinha Inez Estivalet SVIDZINSKI, Marcia Edilaine Lopes CONSOLARO

Abstract

 Vulvovaginal candidiasis (VVC) in HIV-infected women contributed to the impairment of their quality of life. The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) use on the vaginal Candida spp. isolation in HIV-infected compared to HIV-uninfected women. This cross-sectional study included 178 HIV-infected (HIV group) and 200 HIV-uninfected women (control) that were studied at the Specialized Assistance Service (SAE) for sexually transmitted diseases (STD)/AIDS of the city of Maringá, Brazil, from April 1 to October 30, 2011. The yeasts were isolated and identified by phenotypic and molecular methods. The in vitro antifungal susceptibility to fluconazole, itraconazole, nystatin and amphotericin B was tested by the reference microdilution method. Higher frequencies of total vaginal Candida spp. isolation were found in the HIV-infected group than in the control group. However, both groups showed a similar frequency of colonization and VVC. Although C. albicans was the most frequent and sensitive to azolics and polyenes in both HIV-infected and uninfected women, the emerging resistance of C. glabrata to amphotericin B in the HIV-infected women was observed. Although higher frequency of vaginal Candida spp. isolation had been observed in the HIV-infected than in HIV-uninfected women, colonization and VVC showed similar frequency in both groups, indicating that HAART appears to protect against vaginal colonization and VVC.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 4%
Unknown 26 96%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 4%
Unknown 26 96%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2016.
All research outputs
#10,045,365
of 12,556,257 outputs
Outputs from Revista do Instituto de Medicina Tropical de São Paulo
#221
of 251 outputs
Outputs of similar age
#160,025
of 231,971 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de São Paulo
#1
of 1 outputs
Altmetric has tracked 12,556,257 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 251 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,971 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them