Title |
Genetic susceptibility to HPV infection and cervical cancer
|
---|---|
Published in |
Brazilian Journal of Medical and Biological Research, July 1999
|
DOI | 10.1590/s0100-879x1999000700017 |
Pubmed ID | |
Authors |
P.C. Maciag, L.L. Villa |
Abstract |
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Mexico | 1 | 2% |
India | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 47 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 20% |
Researcher | 9 | 18% |
Student > Bachelor | 8 | 16% |
Student > Master | 8 | 16% |
Professor | 2 | 4% |
Other | 5 | 10% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 31% |
Medicine and Dentistry | 12 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Unspecified | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 8% |
Unknown | 12 | 24% |