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Toxicity of synthetic flavorings, nature identical and artificial, to hematopoietic tissue cells of rodents

Overview of attention for article published in Brazilian Journal of Biology, August 2017
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Title
Toxicity of synthetic flavorings, nature identical and artificial, to hematopoietic tissue cells of rodents
Published in
Brazilian Journal of Biology, August 2017
DOI 10.1590/1519-6984.07716
Pubmed ID
Authors

I. M. S. Sales, J. M. Silva, E. S. R. Moura, F. D. S. Alves, F. C. C. Silva, J. M. C. Sousa, A. P. Peron

Abstract

The goal of this study was to analyze cytotoxicity, genotoxicity and mutagenicity to bone marrow cells of mice of nature identical synthetic flavorings, passion fruit and strawberry, and artificial synthetic flavorings, vanilla, chocolate, tutti-frutti and cookie, at doses 0.5; 1.0; 2.0; 5.0 and 10.0 mL/kg. The additives were given to the animals by gavage in a single daily application for seven days. Data were subjected to analysis of variance (ANOVA) followed by post Tukey's post hoc test, p <0.05. Animals treated with 2.0; 5.0 and 10.0 mL/Kg of flavorings chocolate, strawberry and cookie, and 5.0 and 10.0 mL/Kg of flavorings vanilla and passion fruit died on the fifth and sixth day of the experiment, respectively. The doses 0.5 and 1.0 mL/Kg of the six additives significantly reduced erythropoiesis in the examined tissue. Also, treatments 0.5 and 1.0 mL/Kg of chocolate, and 1.0 mL/Kg of strawberry and biscuit induced the formation of micronuclei in the bone marrow erythrocytes, at a significant frequency. Therefore, under the study conditions, the six microingredients analyzed were cytotoxic and genotoxic, and additives strawberry, chocolate and cookie were also mutagenic in at least one of the evaluated doses.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 48%
Student > Master 3 14%
Other 2 10%
Researcher 1 5%
Student > Postgraduate 1 5%
Other 0 0%
Unknown 4 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 29%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Medicine and Dentistry 2 10%
Chemical Engineering 1 5%
Other 2 10%
Unknown 6 29%