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Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone in vitro to rat aortic rings

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, June 2015
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Title
Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone in vitro to rat aortic rings
Published in
Brazilian Journal of Medical and Biological Research, June 2015
DOI 10.1590/1414-431x20144261
Pubmed ID
Authors

J.S. López-Canales, J. Lozano-Cuenca, E. Muãoz-Islas, J.C. Aguilar-Carrasco, O.A. López-Canales, R.M. López-Mayorga, E.F. Castillo-Henkel, I. Valencia-Hernández, C. Castillo-Henkel

Abstract

Amfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vascular effects when applied in vitro to rat aortic rings and, if so, what mechanisms may be involved. We analyzed the effect of amfepramone on phenylephrine-precontracted rat aortic rings with or without endothelium and the influence of inhibitors or blockers on this effect. Amfepramone produced a concentration-dependent vasorelaxation in phenylephrine-precontracted rat aortic rings that was not affected by the vehicle, atropine, 4-AP, glibenclamide, indomethacin, clotrimazole, or cycloheximide. The vasorelaxant effect of amfepramone was significantly attenuated by NG-nitro-L-arginine methyl ester (L-NAME) and tetraethylammonium (TEA), and was blocked by removal of the vascular endothelium. These results suggest that amfepramone had a direct vasorelaxant effect on phenylephrine-precontracted rat aortic rings, and that inhibition of endothelial nitric oxide synthase and the opening of Ca2+-activated K+ channels were involved in this effect.

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The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Student > Bachelor 5 17%
Student > Ph. D. Student 5 17%
Student > Doctoral Student 2 7%
Researcher 1 3%
Other 2 7%
Unknown 10 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 20%
Medicine and Dentistry 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Agricultural and Biological Sciences 2 7%
Arts and Humanities 1 3%
Other 6 20%
Unknown 11 37%