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Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

Overview of attention for article published in Anais da Academia Brasileira de Ciências, May 2015
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Title
Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents
Published in
Anais da Academia Brasileira de Ciências, May 2015
DOI 10.1590/0001-3765201520140364
Pubmed ID
Authors

Pâmela F. Todendi, Elisa I. Klinger, Michele B. Ferreira, Cézane P. Reuter, Miria S. Burgos, Lia G. Possuelo, Andréia R.M. Valim

Abstract

Activation of adipose tissue inflammation is associated with obesity caused by lipid accumulation in adipocytes. Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive protein (CRP) seem to influence metabolic disorders. The present study evaluated whether polymorphisms in the CRP (rs1205) and IL-6 (rs1800795, rs2069845) genes are associated with the development of metabolic disorders in children and adolescents. A cross-sectional study was performed, consisting of 470 students from the municipality of Santa Cruz do Sul, Brazil, aged 7-17 years. Body mass index (BMI) was classified according to overweight and obesity. Genotyping was performed by real-time Polymerase Chain Reaction (PCR). Anthropometric characteristics, biochemical markers, immunological markers and blood pressure were assessed. Descriptive statistics, chi-square and logistic regression were used for the analyses. No association was detected between the rs1800795 polymorphism and the assessed variables. Individuals with the risk genotype in the rs1205 gene were associated with the risk of developing hypercholesterolemia (OR 2.79; CI 1.40, 5.57; p = 0.003). Carriers of the risk genotype in the rs2069845 gene are associated with the risk of developing obesity (OR 3.07; CI 1.08, 8.72; p = 0.03). The polymorphism rs2069845 was associated with obesity and rs1205 was associated with the risk of developing hypercholesterolemia in Brazilian schoolchildren.

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The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Student > Bachelor 12 19%
Researcher 5 8%
Student > Doctoral Student 3 5%
Other 3 5%
Other 10 16%
Unknown 18 28%
Readers by discipline Count As %
Medicine and Dentistry 14 22%
Agricultural and Biological Sciences 7 11%
Biochemistry, Genetics and Molecular Biology 6 9%
Nursing and Health Professions 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 9 14%
Unknown 20 31%