Title |
Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi
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Published in |
AIDS Research and Therapy, October 2011
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DOI | 10.1186/1742-6405-8-38 |
Pubmed ID | |
Authors |
Vijay B Bansode, Simon AA Travers, Amelia C Crampin, Bagrey Ngwira, Neil French, Judith R Glynn, Grace P McCormack |
Abstract |
Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strains and treatment failure. Here, we investigate Drug Resistance Mutations (DRMs) from blood samples obtained at regular intervals from patients on ART (Baseline-22 months) in Karonga District, Malawi. One hundred and forty nine reverse transcriptase (RT) consensus sequences were obtained via nested PCR and automated sequencing from blood samples collected at three-month intervals from 75 HIV-1 subtype C infected individuals in the ART programme. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 200% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 26% |
Other | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Professor | 2 | 6% |
Researcher | 2 | 6% |
Other | 6 | 19% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 42% |
Immunology and Microbiology | 4 | 13% |
Agricultural and Biological Sciences | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Arts and Humanities | 1 | 3% |
Other | 2 | 6% |
Unknown | 7 | 23% |