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Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions

Overview of attention for article published in Carcinogenesis, May 2015
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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4 X users
1 Facebook page


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110 Mendeley
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Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
Published in
Carcinogenesis, May 2015
DOI 10.1093/carcin/bgv033
Pubmed ID

Julia Kravchenko, Emanuela Corsini, Marc A. Williams, William Decker, Masoud H. Manjili, Takemi Otsuki, Neetu Singh, Faha Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A.Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth P. Ryan, Dustin G. Brown, William H. Bisson, Leroy Lowe, H. Kim Lyerly


An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of the cumulative effects of low-dose exposures from the occupational and natural environment, especially if multiple chemicals target the same gene(s) or pathway(s), is a challenge. We reviewed common environmental chemicals and discussed their potential effects on immunosurveillance. Our overarching objective was to review related signaling pathways influencing immune surveillance such as the pathways involving PI3K/Akt, chemokines, TGF-β, FAK, IGF-1, HIF-1α, IL-6, IL-1α, CTLA-4 and PD-1/PDL-1 could individually or collectively impact immunosurveillance. A number of chemicals that are common in the anthropogenic environment such as fungicides (maneb, fluoxastrobin and pyroclostrobin), herbicides (atrazine), insecticides (pyridaben and azamethiphos), the components of personal care products (triclosan and bisphenol A) and diethylhexylphthalate with pathways critical to tumor immunosurveillance. At this time, these chemicals are not recognized as human carcinogens; however, it is known that they these chemicalscan simultaneously persist in the environment and appear to have some potential interfere with the host immune response, therefore potentially contributing to promotion interacting with of immune evasion mechanisms, and promoting subsequent tumor growth and progression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 109 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 24%
Student > Bachelor 15 14%
Student > Ph. D. Student 10 9%
Student > Master 10 9%
Other 8 7%
Other 21 19%
Unknown 20 18%
Readers by discipline Count As %
Medicine and Dentistry 26 24%
Agricultural and Biological Sciences 11 10%
Biochemistry, Genetics and Molecular Biology 10 9%
Environmental Science 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Other 17 15%
Unknown 31 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2015.
All research outputs
of 23,577,654 outputs
Outputs from Carcinogenesis
of 4,819 outputs
Outputs of similar age
of 268,993 outputs
Outputs of similar age from Carcinogenesis
of 41 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,819 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.