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Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

Overview of attention for article published in Breast Cancer Research, August 2011
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Title
Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10
Published in
Breast Cancer Research, August 2011
DOI 10.1186/bcr2917
Pubmed ID
Authors

Petra EA Huijts, Minka van Dongen, Moniek CM de Goeij, Adrian J van Moolenbroek, Freek Blanken, Maaike PG Vreeswijk, Esther M de Kruijf, Wilma E Mesker, Erik W van Zwet, Rob AEM Tollenaar, Vincent THBM Smit, Christi J van Asperen, Peter Devilee

Abstract

SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast cancer risk. Allele-specific regulation of FGFR2 mRNA expression has been reported previously, but the molecular basis for the association of these variants with breast cancer has remained elusive to date.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Argentina 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Student > Master 10 20%
Researcher 8 16%
Other 5 10%
Student > Doctoral Student 4 8%
Other 11 22%
Unknown 2 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 37%
Biochemistry, Genetics and Molecular Biology 12 24%
Medicine and Dentistry 9 18%
Nursing and Health Professions 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 8%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2011.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Breast Cancer Research
#1,534
of 2,052 outputs
Outputs of similar age
#93,372
of 130,321 outputs
Outputs of similar age from Breast Cancer Research
#10
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,321 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.