Title |
Radiogenomic Mapping of Edema/Cellular Invasion MRI-Phenotypes in Glioblastoma Multiforme
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Published in |
PLOS ONE, October 2011
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DOI | 10.1371/journal.pone.0025451 |
Pubmed ID | |
Authors |
Pascal O. Zinn, Bhanu Majadan, Pratheesh Sathyan, Sanjay K. Singh, Sadhan Majumder, Ferenc A. Jolesz, Rivka R. Colen |
Abstract |
Despite recent discoveries of new molecular targets and pathways, the search for an effective therapy for Glioblastoma Multiforme (GBM) continues. A newly emerged field, radiogenomics, links gene expression profiles with MRI phenotypes. MRI-FLAIR is a noninvasive diagnostic modality and was previously found to correlate with cellular invasion in GBM. Thus, our radiogenomic screen has the potential to reveal novel molecular determinants of invasion. Here, we present the first comprehensive radiogenomic analysis using quantitative MRI volumetrics and large-scale gene- and microRNA expression profiling in GBM. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 8 | 3% |
Colombia | 1 | <1% |
Brazil | 1 | <1% |
Netherlands | 1 | <1% |
Spain | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 239 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 50 | 20% |
Student > Ph. D. Student | 49 | 19% |
Student > Doctoral Student | 22 | 9% |
Student > Master | 21 | 8% |
Other | 17 | 7% |
Other | 59 | 23% |
Unknown | 34 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 76 | 30% |
Computer Science | 36 | 14% |
Engineering | 22 | 9% |
Agricultural and Biological Sciences | 21 | 8% |
Biochemistry, Genetics and Molecular Biology | 14 | 6% |
Other | 37 | 15% |
Unknown | 46 | 18% |