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Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Overview of attention for article published in Nature Medicine, May 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Citations

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82 Dimensions

Readers on

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186 Mendeley
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Title
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Published in
Nature Medicine, May 2018
DOI 10.1038/s41591-018-0030-x
Pubmed ID
Authors

Maria Maryanovich, Ali H. Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara, Noboru Asada, Qiaozhi Wei, Xizhe Wang, Paul Ciero, Jianing Xu, Avigdor Leftin, Paul S. Frenette

Abstract

Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multilineage differentiation potential, contributing to the development of blood disorders. The bone marrow microenvironment has recently been suggested to influence HSC aging, but the underlying mechanisms remain largely unknown. Here we show that HSC aging critically depends on bone marrow innervation by the sympathetic nervous system (SNS), as loss of SNS nerves or adrenoreceptor β3 signaling in the bone marrow microenvironment of young mice led to premature HSC aging, as evidenced by appearance of HSC phenotypes reminiscent of physiological aging. Strikingly, supplementation of a sympathomimetic acting selectively on adrenoreceptor β3 to old mice significantly rejuvenated the in vivo function of aged HSCs, suggesting that the preservation or restitution of bone marrow SNS innervation during aging may hold the potential for new HSC rejuvenation strategies.

Twitter Demographics

The data shown below were collected from the profiles of 57 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 186 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 32%
Researcher 28 15%
Student > Master 23 12%
Student > Bachelor 14 8%
Student > Doctoral Student 8 4%
Other 24 13%
Unknown 30 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 47 25%
Agricultural and Biological Sciences 39 21%
Medicine and Dentistry 25 13%
Immunology and Microbiology 20 11%
Neuroscience 4 2%
Other 9 5%
Unknown 42 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2020.
All research outputs
#529,524
of 15,887,811 outputs
Outputs from Nature Medicine
#1,349
of 7,196 outputs
Outputs of similar age
#17,474
of 279,815 outputs
Outputs of similar age from Nature Medicine
#49
of 82 outputs
Altmetric has tracked 15,887,811 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,196 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 61.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,815 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.