In BRCA-mutation carriers, defective estrogen signaling is associated with decreased genome stability and induces tumor development with conspicuous specificity for female organs https://t.co/kOClmGx0EI
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BRCA mutation is an imbalanced defect, crudely inhibiting the upregulation of estrogen receptor (ER) expression and liganded transcriptional activity, whereas ER-repressor functions become predominant. https://t.co/Qr14y4PjwN
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Natural estrogens have numerous benefits in tumor prevention and therapy even in BRCA-mutation carriers. https://t.co/lpnA1EHEOX
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Compensatory high estrogen synthesis may upregulate the interplay between ERs and defective BRCA protein and restores the DNA repairing processes https://t.co/owiILBU1TK