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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Phlebotomus papatasi SP15: mRNA expression variability and amino acid sequence polymorphisms of field populations
|
|---|---|
| Published in |
Parasites & Vectors, May 2015
|
| DOI | 10.1186/s13071-015-0914-2 |
| Pubmed ID | |
| Authors |
Marcelo Ramalho-Ortigão, Iliano V. Coutinho-Abreu, Valdir Q. Balbino, Carlos Alberto S. Figueiredo, Rami Mukbel, Hussan Dayem, Hanafi A. Hanafi, Shabaan S. El-Hossary, Emad El-Din Y. Fawaz, Mahmoud Abo-Shehada, David F. Hoel, Gwen Stayback, Mariha Wadsworth, Douglas A. Shoue, Jenica Abrudan, Neil F. Lobo, Andrew R. Mahon, Scott J. Emrich, Shaden Kamhawi, Frank H. Collins, Mary Ann McDowell |
| Abstract |
The Phlebotomus papatasi salivary protein PpSP15 was shown to protect mice against Leishmania major, suggesting that incorporation of salivary molecules in multi-component vaccines may be a viable strategy for anti-Leishmania vaccines. Here, we investigated PpSP15 predicted amino acid sequence variability and mRNA profile of P. papatasi field populations from the Middle East. In addition, predicted MHC class II T-cell epitopes were obtained and compared to areas of amino acid sequence variability within the secreted protein. The analysis of PpSP15 expression from field populations revealed significant intra- and interpopulation variation.. In spite of the variability detected for P. papatasi populations, common epitopes for MHC class II binding are still present and may potentially be used to boost the response against Le. major infections. Conserved epitopes of PpSP15 could potentially be used in the development of a salivary gland antigen-based vaccine. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 23% |
| Student > Ph. D. Student | 6 | 17% |
| Researcher | 5 | 14% |
| Other | 3 | 9% |
| Student > Bachelor | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 7 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 26% |
| Biochemistry, Genetics and Molecular Biology | 6 | 17% |
| Veterinary Science and Veterinary Medicine | 4 | 11% |
| Immunology and Microbiology | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Other | 2 | 6% |
| Unknown | 8 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2016.
All research outputs
#12,926,518
of 22,808,725 outputs
Outputs from Parasites & Vectors
#2,188
of 5,461 outputs
Outputs of similar age
#118,845
of 265,921 outputs
Outputs of similar age from Parasites & Vectors
#45
of 116 outputs
Altmetric has tracked 22,808,725 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,461 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,921 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.