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Mendeley readers
Attention Score in Context
| Title |
Induction by Antigen of Intrathymic Apoptosis of CD4+CD8+TCRlo Thymocytes in Vivo
|
|---|---|
| Published in |
Science, December 1990
|
| DOI | 10.1126/science.2125367 |
| Pubmed ID | |
| Authors |
Kenneth M. Murphy, Amy B. Heimberger, Dennis Y. Loh |
| Abstract |
In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice transgenic for a T cell receptor (TCR) that reacts to this peptide contain thymocytes that progress from the immature to the mature phenotype. Intraperitoneal administration of the peptide antigen to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes. Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance. |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Singapore | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 144 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 27% |
| Researcher | 34 | 23% |
| Student > Master | 17 | 11% |
| Professor > Associate Professor | 11 | 7% |
| Professor | 9 | 6% |
| Other | 24 | 16% |
| Unknown | 15 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 40% |
| Immunology and Microbiology | 34 | 23% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Medicine and Dentistry | 14 | 9% |
| Chemistry | 2 | 1% |
| Other | 5 | 3% |
| Unknown | 20 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2020.
All research outputs
#4,763,732
of 23,047,237 outputs
Outputs from Science
#39,431
of 78,171 outputs
Outputs of similar age
#4,441
of 59,736 outputs
Outputs of similar age from Science
#64
of 171 outputs
Altmetric has tracked 23,047,237 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,171 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,736 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.