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PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation

Overview of attention for article published in Molecular Brain, June 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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Citations

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31 Dimensions

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Title
PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation
Published in
Molecular Brain, June 2015
DOI 10.1186/s13041-015-0124-z
Pubmed ID
Authors

Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie, Zhengping Jia

Abstract

p21-activated kinase 1 (PAK1) is a serine/threonine kinase known to be activated by the Rho family small GTPases and to play a key role in cytoskeletal reorganization, spine morphology and synaptic plasticity. PAK1 is also implicated in a number of neurodevelopmental and neurodegenerative diseases, including autism, intellectual disability and Alzheimer's disease. However, the role of PAK1 in early brain development remains unknown. In this study, we employed genetic manipulations to investigate the role of PAK1 in the cerebral cortical development in mice. We showed that compared to the wild type littermates, PAK1 knockout mice have a reduction in the number of pyramidal neurons in several layers of the cerebral cortex, which is associated with a smaller pool of neural progenitor cells and impaired neuronal migration. These results suggest that PAK1 regulates cortical development by promoting the proliferation of neural progenitor cells and facilitating the migration of these neurons to specific regions of the cortex.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 28%
Student > Ph. D. Student 12 19%
Student > Bachelor 9 14%
Student > Master 7 11%
Professor 4 6%
Other 10 16%
Unknown 4 6%
Readers by discipline Count As %
Neuroscience 16 25%
Agricultural and Biological Sciences 14 22%
Biochemistry, Genetics and Molecular Biology 7 11%
Psychology 6 9%
Medicine and Dentistry 5 8%
Other 9 14%
Unknown 7 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2017.
All research outputs
#7,215,850
of 22,808,725 outputs
Outputs from Molecular Brain
#348
of 1,106 outputs
Outputs of similar age
#86,575
of 266,891 outputs
Outputs of similar age from Molecular Brain
#6
of 16 outputs
Altmetric has tracked 22,808,725 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,891 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.