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Limitations of safranin ‘O’ staining in proteoglycan-depleted cartilage demonstrated with monoclonal antibodies

Overview of attention for article published in Histochemistry and Cell Biology, March 1988
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

blogs
1 blog
patent
2 patents

Citations

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94 Dimensions

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114 Mendeley
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Title
Limitations of safranin ‘O’ staining in proteoglycan-depleted cartilage demonstrated with monoclonal antibodies
Published in
Histochemistry and Cell Biology, March 1988
DOI 10.1007/bf00489922
Pubmed ID
Authors

K. L. Camplejohn, S. A. Allard

Abstract

The intensity of safranin 'O' staining is directly proportional to the proteoglycan content in normal cartilage. Safranin 'O' has thus been used to demonstrate any changes that occur in articular disease. In this study, staining patterns obtained using monoclonal antibodies against the major components of cartilage proteoglycan chondroitin sulphate (anti CS) and keratan sulphate (anti KS), have been compared with those obtained with safranin 'O' staining, in both normal and arthritic tissues. In cartilage where safranin 'O' staining was not detectable, the monoclonal antibodies revealed the presence of both keratan and chondroitin sulphate. Thus, safranin 'O' is not a sensitive indicator of proteoglycan content in diseases where glycosaminoglaycan loss from cartilage has been severe.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 <1%
United Kingdom 1 <1%
Unknown 112 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 21%
Student > Master 19 17%
Researcher 15 13%
Student > Bachelor 14 12%
Student > Doctoral Student 7 6%
Other 17 15%
Unknown 18 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 22%
Engineering 24 21%
Medicine and Dentistry 22 19%
Biochemistry, Genetics and Molecular Biology 8 7%
Materials Science 4 4%
Other 12 11%
Unknown 19 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2019.
All research outputs
#4,312,846
of 25,374,917 outputs
Outputs from Histochemistry and Cell Biology
#86
of 1,236 outputs
Outputs of similar age
#1,326
of 12,256 outputs
Outputs of similar age from Histochemistry and Cell Biology
#1
of 3 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,236 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 12,256 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them