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Changes in antibody reactivity to Borrelia burgdorferi three months after a tick bite. A cohort of 1,886 persons.

Overview of attention for article published in Clinical and Vaccine Immunology (formerly CDLI)
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

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Title
Changes in antibody reactivity to Borrelia burgdorferi three months after a tick bite. A cohort of 1,886 persons.
Published in
Clinical and Vaccine Immunology (formerly CDLI)
DOI 10.1128/cvi.00026-15
Pubmed ID
Authors

Ram B. Dessau, Linda Fryland, Peter Wilhelmsson, Christina Ekerfelt, Dag Nyman, Pia Forsberg, Per-Eric Lindgren

Abstract

Lyme borreliosis is a tick-borne disease caused by the bacterium Borrelia burgdorferi. The most frequent clinical manifestation is a rash called erythema migrans. Changes in antibody reactivity to B. burgdorferi three months after a tick bite are measured using ELISA assays. One assay is based on native purified flagella-antigen (IgG) and the other assay is based on a recombinant antigen called C6 (IgG or IgM). Paired samples were taken at the time of a tick bite and three months later from 1,886 persons in Sweden and the Åland Islands. The seroconversion or relative change is defined as the measurement units from the second sample divided by the first sample. Thresholds for the minimum level of significant change were defined as the 2.5% percentile to represent the random error level. The thresholds were 2.7 fold rises for the flagella IgG and 1.8 fold rises for the C6 assays. 102/101 (5.4%) of 1,886 persons had a significant rise in antibody reactivity in the flagella or C6 assay. Among 40 cases with a diagnosis of Lyme borreliosis the sensitivity of a rise in antibodies was 33% and 50% to the flagella antigen and the C6 antigen respectively. Graphical methods to display the antibody response and methods to choose thresholds for a rise in relative antibody reactivity are shown and discussed. In conclusion, 5.4% of people with tick bites developed a rise in borrelia-specific antibodies above the 2.5% percentile in either ELISA assay, but only 40 (2.1%) developed clinical Lyme borreliosis.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 19%
Netherlands 1 6%
Unknown 12 75%

Demographic breakdown

Readers by professional status Count As %
Other 5 31%
Researcher 5 31%
Librarian 3 19%
Professor 1 6%
Student > Postgraduate 1 6%
Other 1 6%
Readers by discipline Count As %
Medicine and Dentistry 6 38%
Agricultural and Biological Sciences 2 13%
Social Sciences 2 13%
Philosophy 1 6%
Environmental Science 1 6%
Other 4 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2015.
All research outputs
#3,334,009
of 8,203,947 outputs
Outputs from Clinical and Vaccine Immunology (formerly CDLI)
#393
of 826 outputs
Outputs of similar age
#78,509
of 222,199 outputs
Outputs of similar age from Clinical and Vaccine Immunology (formerly CDLI)
#4
of 22 outputs
Altmetric has tracked 8,203,947 research outputs across all sources so far. This one has received more attention than most of these and is in the 58th percentile.
So far Altmetric has tracked 826 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,199 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.