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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus
|
|---|---|
| Published in |
PLOS ONE, June 2015
|
| DOI | 10.1371/journal.pone.0128720 |
| Pubmed ID | |
| Authors |
Koshiro Inoue, Masahiro Okamoto, Junko Shibato, Min Chul Lee, Takashi Matsui, Randeep Rakwal, Hideaki Soya |
| Abstract |
Our six-week treadmill running training (forced exercise) model has revealed that mild exercise (ME) with an intensity below the lactate threshold (LT) is sufficient to enhance spatial memory, while intense exercise (IE) above the LT negates such benefits. To help understand the unrevealed neuronal and signaling/molecular mechanisms of the intensity-dependent cognitive change, in this rat model, we here investigated plasma corticosterone concentration as a marker of stress, adult hippocampal neurogenesis (AHN) as a potential contributor to this ME-induced spatial memory, and comprehensively delineated the hippocampal transcriptomic profile using a whole-genome DNA microarray analysis approach through comparison with IE. Results showed that only IE had the higher corticosterone concentration than control, and that the less intense exercise (ME) is better suited to improve AHN, especially in regards to the survival and maturation of newborn neurons. DNA microarray analysis using a 4 × 44 K Agilent chip revealed that ME regulated more genes than did IE (ME: 604 genes, IE: 415 genes), and only 41 genes were modified with both exercise intensities. The identified molecular components did not comprise well-known factors related to exercise-induced AHN, such as brain-derived neurotrophic factor. Rather, network analysis of the data using Ingenuity Pathway Analysis algorithms revealed that the ME-influenced genes were principally related to lipid metabolism, protein synthesis and inflammatory response, which are recognized as associated with AHN. In contrast, IE-influenced genes linked to excessive inflammatory immune response, which is a negative regulator of hippocampal neuroadaptation, were identified. Collectively, these results in a treadmill running model demonstrate that long-term ME, but not of IE, with minimizing running stress, has beneficial effects on increasing AHN, and provides an ME-specific gene inventory containing some potential regulators of this positive regulation. This evidence might serve in further elucidating the mechanism behind ME-induced cognitive gain. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 5 | 36% |
| Canada | 1 | 7% |
| Unknown | 8 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 93% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| Unknown | 194 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 32 | 16% |
| Student > Bachelor | 30 | 15% |
| Student > Ph. D. Student | 28 | 14% |
| Researcher | 14 | 7% |
| Student > Doctoral Student | 8 | 4% |
| Other | 29 | 15% |
| Unknown | 55 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 20% |
| Agricultural and Biological Sciences | 26 | 13% |
| Medicine and Dentistry | 19 | 10% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Psychology | 11 | 6% |
| Other | 27 | 14% |
| Unknown | 61 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2016.
All research outputs
#4,216,070
of 24,143,470 outputs
Outputs from PLOS ONE
#67,465
of 207,525 outputs
Outputs of similar age
#50,871
of 270,594 outputs
Outputs of similar age from PLOS ONE
#1,495
of 6,851 outputs
Altmetric has tracked 24,143,470 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 207,525 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 6,851 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.