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In Vitro Activity of Clofazimine against Nontuberculous Mycobacteria Isolated in Beijing, China

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

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4 Dimensions

Readers on

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8 Mendeley
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Title
In Vitro Activity of Clofazimine against Nontuberculous Mycobacteria Isolated in Beijing, China
Published in
Antimicrobial Agents and Chemotherapy, June 2018
DOI 10.1128/aac.00072-18
Pubmed ID
Authors

Jingjing Luo, Xia Yu, Guanglu Jiang, Yuhong Fu, Fengmin Huo, Yifeng Ma, Fen Wang, Yuanyuan Shang, Qian Liang, Yi Xue, Hairong Huang

Abstract

Due to the natural resistance of non-tuberculous mycobacteria(NTM) to lots of antibiotics,treatment of diseases caused by NTM is often long-termed but less successful.The main goal of this study was to evaluate the in vitro susceptibility to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing,China. Furthermore,47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium(SGM) species.The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well.Clofazimine exhibited excellent activities against both reference strains and clinical isolates of different SGM species,and most of the strains had MICs far below 1μg/ml.Although the majority clinical isolates of M. abscessus and M. fortuitum had MICs higher than 2μg/ml, 17 out of the 30reference strains of different RGM species had MICs below 1μg/ml in vitroAccording tothe MIC distributions, the tentative epidemiological cut-off (ECOFF)values for M. kansassii,M. aviumand M. intracellulare were defined at 0.5μg/ml,1μg/ml and 2μg/ml, respectively. Intriguingly, single directional cross-resistance between bedaquiline and Cfz resistant isolates was observed among the tested NTM species.This study demonstrate that clofazimine had strong activities against most SGM species in vitro, and some RGM species as well.The data provided important insights on the possible clinical application of Cfz to treat NTM infections.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 25%
Student > Ph. D. Student 1 13%
Student > Postgraduate 1 13%
Student > Doctoral Student 1 13%
Student > Bachelor 1 13%
Other 1 13%
Unknown 1 13%
Readers by discipline Count As %
Immunology and Microbiology 2 25%
Biochemistry, Genetics and Molecular Biology 2 25%
Nursing and Health Professions 1 13%
Unspecified 1 13%
Medicine and Dentistry 1 13%
Other 0 0%
Unknown 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2018.
All research outputs
#1,534,599
of 13,138,880 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#1,785
of 11,545 outputs
Outputs of similar age
#52,107
of 270,142 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#84
of 206 outputs
Altmetric has tracked 13,138,880 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,545 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,142 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 206 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.